Which statement best differentiates Type 1 and Type 2 diabetes pathophysiology?

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Multiple Choice

Which statement best differentiates Type 1 and Type 2 diabetes pathophysiology?

The main idea is that Type 1 and Type 2 diabetes arise from different problems with insulin—production versus action. Type 1 involves autoimmune destruction of pancreatic beta cells, leading to little or no insulin production. Type 2 starts with insulin resistance in peripheral tissues, so the body makes more insulin at first but tissues don’t respond well; over time, beta-cell function may decline, causing a relative deficiency. This combination—autoimmune beta-cell destruction in Type 1 and insulin resistance with relative deficiency in Type 2—best differentiates the two. The other descriptions misstate the primary issue (for example, suggesting a glucagon deficiency or flipping which type has insulin resistance), which doesn’t reflect how each condition actually develops.

The main idea is that Type 1 and Type 2 diabetes arise from different problems with insulin—production versus action. Type 1 involves autoimmune destruction of pancreatic beta cells, leading to little or no insulin production. Type 2 starts with insulin resistance in peripheral tissues, so the body makes more insulin at first but tissues don’t respond well; over time, beta-cell function may decline, causing a relative deficiency. This combination—autoimmune beta-cell destruction in Type 1 and insulin resistance with relative deficiency in Type 2—best differentiates the two. The other descriptions misstate the primary issue (for example, suggesting a glucagon deficiency or flipping which type has insulin resistance), which doesn’t reflect how each condition actually develops.

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