Which organ is primarily responsible for detoxification that affects drug toxicity in hepatitis?

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Multiple Choice

Which organ is primarily responsible for detoxification that affects drug toxicity in hepatitis?

Detoxification of drugs is mainly performed by the liver through hepatic metabolism. Hepatocytes use enzymes, especially the cytochrome P450 system for phase I reactions and various conjugation pathways for phase II, to convert lipophilic drugs into more water-soluble forms that can be excreted by the kidneys or via bile. In hepatitis, inflammation and impaired liver function reduce these metabolic processes, so drugs are cleared more slowly and can accumulate to toxic levels. The kidneys handle elimination of metabolites once they’re water-soluble, but they’re not the primary detoxifier for most drugs, and the lungs and spleen don’t play major roles in drug detoxification. Therefore, the organ most responsible for detoxification affecting drug toxicity in hepatitis is the liver.

Detoxification of drugs is mainly performed by the liver through hepatic metabolism. Hepatocytes use enzymes, especially the cytochrome P450 system for phase I reactions and various conjugation pathways for phase II, to convert lipophilic drugs into more water-soluble forms that can be excreted by the kidneys or via bile. In hepatitis, inflammation and impaired liver function reduce these metabolic processes, so drugs are cleared more slowly and can accumulate to toxic levels. The kidneys handle elimination of metabolites once they’re water-soluble, but they’re not the primary detoxifier for most drugs, and the lungs and spleen don’t play major roles in drug detoxification. Therefore, the organ most responsible for detoxification affecting drug toxicity in hepatitis is the liver.

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