Which laboratory finding is most indicative of rhabdomyolysis?

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Multiple Choice

Which laboratory finding is most indicative of rhabdomyolysis?

Rhabdomyolysis is a condition where skeletal muscle fibers break down and release their contents into the bloodstream. The most telling laboratory sign is a marked rise in creatine kinase, the enzyme abundant in muscle. Because CK leaks out of damaged muscle cells, its level directly reflects the extent of muscle injury, making it the most sensitive and timely indicator. CK begins to rise within hours after injury and can peak in the first couple of days, remaining elevated for several days as the muscles recover. While other enzymes like AST or ALT can also be elevated, they’re not as specific to muscle injury and can be seen with liver problems. Elevated CK thus stands out as the best diagnostic clue for rhabdomyolysis, whereas a normal CK would argue against it.

Rhabdomyolysis is a condition where skeletal muscle fibers break down and release their contents into the bloodstream. The most telling laboratory sign is a marked rise in creatine kinase, the enzyme abundant in muscle. Because CK leaks out of damaged muscle cells, its level directly reflects the extent of muscle injury, making it the most sensitive and timely indicator. CK begins to rise within hours after injury and can peak in the first couple of days, remaining elevated for several days as the muscles recover. While other enzymes like AST or ALT can also be elevated, they’re not as specific to muscle injury and can be seen with liver problems. Elevated CK thus stands out as the best diagnostic clue for rhabdomyolysis, whereas a normal CK would argue against it.

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