What is the LDL-C target for very high-risk ASCVD patients per current guidelines?

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Multiple Choice

What is the LDL-C target for very high-risk ASCVD patients per current guidelines?

Lowering LDL cholesterol to very low levels in people with established ASCVD reduces the chance of another heart attack or stroke. For those at very high risk, guidelines set a target of less than 70 mg/dL (about 1.8 mmol/L) after maximally tolerated statin therapy. This level is chosen because evidence shows further risk reduction with aggressive lowering in secondary prevention. If the goal isn’t reached with statins alone, add nonstatin therapies like ezetimibe, and if needed or appropriate, consider PCSK9 inhibitors to push LDL-C below 70 mg/dL.

Lowering LDL cholesterol to very low levels in people with established ASCVD reduces the chance of another heart attack or stroke. For those at very high risk, guidelines set a target of less than 70 mg/dL (about 1.8 mmol/L) after maximally tolerated statin therapy. This level is chosen because evidence shows further risk reduction with aggressive lowering in secondary prevention. If the goal isn’t reached with statins alone, add nonstatin therapies like ezetimibe, and if needed or appropriate, consider PCSK9 inhibitors to push LDL-C below 70 mg/dL.

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