Gamma-carboxylation is required for which clotting factors?

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Multiple Choice

Gamma-carboxylation is required for which clotting factors?

Gamma-carboxylation adds gamma-carboxyglutamate residues to certain clotting factors, enabling them to bind calcium and attach to phospholipid surfaces needed for proper coagulation. This vitamin K–dependent modification occurs in factors II (prothrombin), VII, IX, and X, allowing them to participate effectively in the cascade. Proteins C and S are also vitamin K–dependent, but they act as regulatory, not procoagulant, factors. Therefore, the clotting factors that require gamma-carboxylation are II, VII, IX, and X.

Gamma-carboxylation adds gamma-carboxyglutamate residues to certain clotting factors, enabling them to bind calcium and attach to phospholipid surfaces needed for proper coagulation. This vitamin K–dependent modification occurs in factors II (prothrombin), VII, IX, and X, allowing them to participate effectively in the cascade. Proteins C and S are also vitamin K–dependent, but they act as regulatory, not procoagulant, factors. Therefore, the clotting factors that require gamma-carboxylation are II, VII, IX, and X.

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