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Multiple Choice

Dysuria with discharge in a sexually active young man is most commonly due to which infection?

The main idea here is that non-gonococcal urethritis is the most common cause of urethral discharge with dysuria in sexually active young men, and the usual culprit is Chlamydia trachomatis. Chlamydia infections often produce mild or even unnoticed symptoms, but when symptoms appear they commonly include dysuria and a discharge that can be mucopurulent. This makes Chlamydia the most frequent etiologic agent in this presentation. Gonorrhea can cause similar symptoms, but it tends to present with a more purulent discharge and can be more acute. Herpes typically presents with painful genital ulcers rather than a simple discharge, and syphilis begins with a painless lesion rather than urethral discharge in most cases. Diagnosis is by nucleic acid amplification testing on urine or a urethral swab for both Chlamydia and Gonorrhea, since co-infection is possible and treatment decisions often cover both.

The main idea here is that non-gonococcal urethritis is the most common cause of urethral discharge with dysuria in sexually active young men, and the usual culprit is Chlamydia trachomatis. Chlamydia infections often produce mild or even unnoticed symptoms, but when symptoms appear they commonly include dysuria and a discharge that can be mucopurulent. This makes Chlamydia the most frequent etiologic agent in this presentation.

Gonorrhea can cause similar symptoms, but it tends to present with a more purulent discharge and can be more acute. Herpes typically presents with painful genital ulcers rather than a simple discharge, and syphilis begins with a painless lesion rather than urethral discharge in most cases.

Diagnosis is by nucleic acid amplification testing on urine or a urethral swab for both Chlamydia and Gonorrhea, since co-infection is possible and treatment decisions often cover both.