During a transfusion reaction with urticaria, which medication is commonly given to treat the reaction?

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Histamine release during a transfusion reaction drives the urticaria, itching, and flushing. The way to relieve these symptoms is to block the effects of histamine on its receptors. Diphenhydramine is an antihistamine that blocks H1 receptors, reducing the wheal-and-flare reaction and itching characteristic of urticaria. That makes it the common choice for this scenario. The other drugs listed don't address histamine-driven symptoms: lidocaine is a local anesthetic/antiarrhythmic, ketamine is an anesthetic, and atropine is an antimuscarinic.